Swimming against the tide: a study of a neighbourhood trying to rediscover its ‘reason for being’– the case of South Bank, Redcar and Cleveland

Many of the programmes and initiatives to regenerate deprived neighbourhoods appear to have had limited lasting impact. It has been argued that one reason for this is that we still have little real understanding of the nature and scale of the problems some communities face (Bernt, 2009). This paper attempts to add to our knowledge through close study of an area with multiple problems and a history of failed regeneration attempts. An in-depth case study undertaken to explore the current situation and future prospects of South Bank, a small neighbourhood in the North East of England, highlights transferable knowledge which may be applied to other regeneration areas. The analysis considers the nature and consequences of industrial decline; entrenched deprivation; the stigmatization of communities; the value of community consultation and the potential impact of retail-led regeneration. We question whether negative stigma attached to places can be changed and we ask what the future may hold for deprived communities now that public sector funding has largely dried up, and we consider an alternative approach: the potential impacts of private sector retail-led regeneration in the absence of public sector funding

'It'll get worse before it gets better': Local experiences of living in a regeneration area

The negative consequences of living in deprived neighbourhoods for residents’ quality of life are well documented. Area-based regeneration initiatives are invariably concerned with improving local quality of life over the long term. The process of regeneration, however, can itself directly result in immediate and potentially lasting negative effects for local communities. This paper discusses some of the ways in which living in an area undergoing regeneration can adversely affect inhabitants’ quality of life, including problems associated with voids, relocation, demolitions, environmental quality, complexity, funding issues, uncertainty, frustration, fear for the future and consultation fatigue. A case study approach draws examples from a deprived neighbourhood in the North East of England. The conclusion discusses some of the possible implications for future regeneration policy, including: the importance of ongoing communication between professionals and communities; the need to value local people’s experience, judgement and the contribution they can make to local decision-making processes; recognition that successful regeneration can take many years; and the implications of current UK government policy

I\u27m Done With Rag - Time

https://digitalcommons.library.umaine.edu/mmb-vp/3205/thumbnail.jp

Sbf/MTMR13 coordinates PI(3)P and Rab21 regulation in endocytic control of cellular remodeling.

Cells rely on the coordinated regulation of lipid phosphoinositides and Rab GTPases to define membrane compartment fates along distinct trafficking routes. The family of disease-related myotubularin (MTM) phosphoinositide phosphatases includes catalytically inactive members, or pseudophosphatases, with poorly understood functions. We found that Drosophila MTM pseudophosphatase Sbf coordinates both phosphatidylinositol 3-phosphate (PI(3)P) turnover and Rab21 GTPase activation in an endosomal pathway that controls macrophage remodeling. Sbf dynamically interacts with class II phosphatidylinositol 3-kinase and stably recruits Mtm to promote turnover of a PI(3)P subpool essential for endosomal trafficking. Sbf also functions as a guanine nucleotide exchange factor that promotes Rab21 GTPase activation associated with PI(3)P endosomes. Of importance, Sbf, Mtm, and Rab21 function together, along with Rab11-mediated endosomal trafficking, to control macrophage protrusion formation. This identifies Sbf as a critical coordinator of PI(3)P and Rab21 regulation, which specifies an endosomal pathway and cortical control

The sodium-chlorinity ratio of ocean waters from the Northwest Pacific

Ocean water is a complex solution of many ions. The concentration of this solution varies considerably from place to place but it has been repeatedly shown that the relative concentration of the ions to each other is remarkably constant…